By Stefan Guhlke (auth.), Jan Bucerius, Hojjat Ahmadzadehfar, Hans-Jürgen Biersack (eds.)
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that's common for the imaging of myocardial perfusion, in addition to various malignant and benign illnesses. 99mTc-Sestamibi – medical purposes presents a close and informative evaluation of virtually all of the oncologic and non-oncologic functions of 99mTc-sestamibi SPECT, together with numerous rather infrequent symptoms. various disease-related protocols for 99mTc-sestamibi SPECT are offered, and for every illness a accomplished precis of the appropriate pathology and epidemiology is supplied. all through, there's a powerful emphasis at the useful points of use of this renowned tracer, together with directions for the training of a number of commercially to be had tracer kits. scientific practitioners will locate this e-book to be a useful consultant to the applying and advantages of 99mTc-sestamibi SPECT in either the inpatient and the outpatient setting.
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Extra resources for 99mTc-Sestamibi: Clinical Applications
Heiden 61 hyperplastic parathyroids. The sensitivity for localizing the diseased glands in patients with primary HPT (91%) was higher than that in patients with secondary HPT (83%). Signiﬁcantly greater average parathyroid-to-thyroid count ratios on early and delayed images were observed in the diseased glands. It was pointed out that the uptake of Sestamibi in the hyperfunctional glands is dependent on gland size and the amount of cellular components, chief cells and oxyphil cells. 6 Parathyroid Imaging in Patients with Concomitant Thyroid Disease One of the main problems of false-positives in parathyroid imaging is multinodular goitre.
Konijnenberg 14. Boström P-A, Diemer H, Leide S, Lilja B, Bergqvist D (1993) 99Tcm-Sestamibi uptake in the leg muscles and in the myocardium in patients with intermittent claudication. Angiology 44:971–976 15. Berman DS, Kang X, Tamarappoo B, Wolak A, Hayes SW, Nakazato R, Thomson LE, Kite F, Cohen I, Slomka PJ, Einstein AJ, Friedman JD (2009) Stress thallium-201/rest technetium99m sequential dual isotope high-speed myocardial perfusion imaging. JACC Cardiovasc Imaging 2:273–282 16. Stabin MG, Sparks RB, Crowe E.
14] investigated the effect of intravenous calcitriol on parathyroid gland activity using double-phase 99mTc-Sestamibi scintigraphy. After 1 year of treatment with calcitriol, parathormone levels decreased signiﬁcantly in 95% of the patients. After therapy, Sestamibi-positive areas decreased in 29% of the patients. These authors suggest Sestamibi scintigraphy as a reliable exploratory tool in predicting the response to treatment with intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism.