Advanced Mechanical Models of DNA Elasticity by Yakov M Tseytlin

By Yakov M Tseytlin

Advanced Mechanical versions of DNA Elasticity comprises insurance on 17 diverse DNA versions and the function of elasticity in organic features with vast references. the radical complex helicoidal version defined displays the direct connection among the molecule helix constitution and its particular homes, together with nonlinear good points and transitions. It presents an creation to the kingdom of the sphere of DNA mechanics, identified and established versions with their brief research, in addition to assurance on experimental tools and information, the effect of electric, magnetic, ionic stipulations at the patience size, and dynamics with viscosity effect. It then addresses the necessity to comprehend the character of the non-linear overstretching transition of DNA less than strength and why DNA has a destructive twist-stretch coupling.

  • Includes insurance of 17 modern types of DNA mechanics with analysis
  • Provides comparability of DNA and RNA mechanical features
  • Covers advances in experimental concepts together with AFM, X-ray, and optical tweezers
  • Contains huge references for extra reading

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Nat. Edu. , 1999. Sequence-dependent mechanics of single DNA molecules. Nature Struct. Biol. 6 (4), 346–349. , 1998. Diversity of prokaryotic chromosomal proteins and the origin of the nucleosome. Cell. Mol. Life Sci. 54 (12), 1350–1364. , 2015. Block copolymer-nanoparticle composites: structure, functional properties, and processing. Prog. Polym. Sci. 40, 33–62. , 1994. The Kirchhoff elastic rod, the nonlinear Schrödinger equation, and DNA supercoiling. J. Chem. Phys. 101 (6), 5186–5200. , 1984.

J. 74, 132–137. , 1998. Stretched and overwound DNA form a Pauling-like structure with exposed bases. Proc. Natl. Acad. Sci. USA 95, 14152–14157. , 2003. Stretching DNA and RNA to probe their interactions with proteins. Curr. Opin. Struct. Biol. 13, 266–274. , 2010. A model for Structure and thermodynamics of ssDNA and dsDNA near a surface: a coarse grained approach. Comput. Phys. Commun. 181 (12), 2001–2007. , 1997. Ionic effects on the elasticity of single DNA molecules. Proc. Natl. Acad. Sci.

4 nm. 8 nm. Z-DNA does not have a major groove; minor groove is very narrow and deep. The B to Z helical transformation can be induced in supercoiled DNA by untwisting the macromolecule. Since these transformations are cooperative in nature, statistical mechanical methods offer a convenient approach to understanding the underlying physicochemical basis. An Ising statistical mechanical model with sequence assumption was developed. In the proposed Ising model (Ghosh, 1992), the helical states of DNA are considered at first approximation to exist in righthanded (R) and left-handed (L) forms in equilibrium with each other, that is, R↔L.

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