Antimicrobial Drug Resistance: Clinical and Epidemiological by Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD

By Lesley McGee, Keith P. Klugman (auth.), Douglas L. Mayers MD (eds.)

The volumes integrated in Antimicrobial Drug Resistance characterize the 1st entire, multidisciplinary reference masking the realm of antimicrobial drug resistance in micro organism, fungi, viruses, and parasites from simple technological know-how, medical, and epidemiological perspectives.

The first quantity, Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, is devoted to the organic foundation of drug resistance and potent avenues for drug improvement. With the emergence of extra drug-resistant traces, the method of facing the drug resistance challenge needs to contain the study of alternative points of the mechanisms of bacterial resistance and the dissemination of resistance genes in addition to learn using new genomic info. those methods will allow the layout of novel techniques to strengthen new antibiotics and defend the effectiveness of presently to be had ones.

The moment quantity, Antimicrobial Drug Resistance, medical and Epidemiological Aspects, is dedicated to the medical points of drug resistance. even supposing there's proof that constrained use of a selected antibiotic could be by means of a lessen in drug resistance to that agent, drug resistance keep watch over isn't simply accomplished. hence, the infectious affliction doctor calls for enter from the medical microbiologist and an infection keep an eye on expert to make knowledgeable offerings for the potent therapy of varied lines of drug-resistant pathogens in person patients.

This 2-volume set is a crucial reference for college students in microbiology, infectious ailment physicians, clinical scholars, simple scientists, drug improvement researchers, microbiologists, epidemiologists, and public well-being practitioners.

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Hansman D, Bullen MM. A resistant pneumococcus. Lancet 1967;1:264–265 47. Hansman D, Glasgow H, Sturt J, Devitt HL, Douglas R. Increased resistance to penicillin of pneumococci isolated from man. N Engl J Med 1971;284:175–177 48. Naraqi S, Kirkpatrick GP, Kabins S. Relapsing pneumococcal meningitis: isolation of an organism with decreased susceptibility to penicillin G. J Pediatr 1974;85:671–673 49. Appelbaum PC, Bhamjee A, Scragg JN, Hallett AF, Bowen AJ, Cooper RC. Streptococcus pneumoniae resistant to penicillin and chloramphenicol.

Viridans group streptococci are donors in horizontal transfer of toposiomerase IV genes to Streptococcus pneumoniae. Antimicrob Agents Chemother 2003;47:2072–2081 108. Bast DJ, de Azavedo JC, Tam TY, et al. Interspecies recombination contributes minimally to fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother 2001;45:2631–2634 109. Pletz MWR, McGee L, Beall B, Whitney CG, Klugman KP. Interspecies recombination in type II topoisomerase genes is 691 110. 111. 112. 113.

VGS with wild-type PBSs are susceptible to beta-lactam antibiotics (22). In order to become resistant, they have to decrease the affinity of beta-lactams to the high-molecularweight PBPs. This can be achieved by amino acid substitutions in the transpeptidase domain of the PBPs (19, 22). One point mutation can result in slight increase in the penicillin MIC. Normally more than one mutation is needed for intermediate-level beta-lactam resistance. Highly resistant strains have accumulated several mutations in the PBPs.

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