By Professor Dr. med. Helmut Löffler, Professor Dr. med. Johann Rastetter, Professor Dr. med. Dr. phil. T. Haferlach (auth.)
This sixth variation of the atlas has built-in the 2001 WHO class and made use of figures and outlines to rfile lately defined forms of leukemia and lymphoma. The latter contain leukemias of dendritic cells, infrequent lymphomas and protracted polyclonal B lymphocytosis, which takes a different position within the classification.
The quantity covers the entire microscopic equipment in hematology that shape the root of analysis in addition to the result of glossy immunologic, cytogenetic and molecular-genetic research. detailed emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that may shape the root for leading edge therapies.
Normal effects and pathological findings are in comparison, and a number of the findings made in the course of remedy are depicted. All in all of the Atlas of scientific Hematology represents an entire and worthwhile reference paintings which can be found in each hematologic and oncologic division in addition to in medical laboratories for on-line diagnostics and medical research.
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The Pelger-Huet anomaly is harmless in its effect on leukocyte function. ” Alder-Reilly Anomaly (Fig. 10 d – f) Here the granulocytes contain large, bluish granules that often resemble those of promyelocytes; monocytes have large granules, too. The abnormal granulation is especially marked in eosinophils, which appear basophilic rather than eosinophilic (Fig. 10 e, left). The lymphocytes also contain particularly large azurophilic granules (Fig. 10 f). Carriers of this anomaly frequently have associated bone and joint deformities (gargoylism).
11 a – f) This condition affects virtually all leukocytes. The neutrophils contain irregular, grayish-blue cytoplasmic inclusions 1 – 3 lm in diameter. These bodies are sharply demarcated and contain peroxidase and also CE in some cases, identifying them as primary granules (Fig. 11 a, b, e, f). The granules of eosinophilic leukocytes are also enlarged to 2 – 3 times the size of normal eosinophilic granules. They are round to oval in shape and variable in size. Most lymphocytes and monocytes also contain intensely red-staining granules 1 – 2 lm in diameter.
Polychromasia occurs when mature erythrocytes show increased staining with basic dyes (violet stain) in addition to hemoglobin staining. It is usually associated with reticulocytosis. Polychromasia occurs in red cells that still have a relatively high RNA content and in which hemoglobin synthesis is not yet complete. It is especially common in chronic hemolytic anemias. The variable staining of the erythrocytes is also termed anisochromia. Cabot rings are remnants of spindle fibers and are a product of abnormal regeneration (see also Fig.