Chronic Myelocytic Leukemia and Interferon: by C. Fonatsch, G. Gradl (auth.), Prof. Dr. med. Dieter Huhn,

By C. Fonatsch, G. Gradl (auth.), Prof. Dr. med. Dieter Huhn, Prof. Dr. med. Klaus Peter Hellriegel, Prof. Dr. med. Norbert Niederle (eds.)

Contents: Cytogenetic Findings in Myeloproliferative Disorders.- Molecular Analyses of persistent Myelocytic Leukemias.- Molecular organic research in persistent Myelogenous Leukemia sufferers present process Interferon Therapy.- impact of Recombinant Interferon-Alpha-2 at the progress of Hematopoietic Progenitor Cells in power Myelogenous Leukemia and Its courting to the medical Efficacy.- In Vitro results of Recombinant Human Tumor Necrosis Factor-Alpha and Interferon-Gamma on basic and Leukemic Myelopoiesis.- Demonstration of Interferon-Alpha Receptors in Cultured cellphone traces and in Myeloid Cells from sufferers with Acute or power Myeloid Leukemia.- Differential legislation of mobilephone Membrane Receptors for Interferon-Gamma and -Alpha on Peripheral Blood Cells of sufferers with persistent Myelogenous Leukemia in the course of Interferon-Gamma/-Alpha Therapy.- experiences of Interferon as a Regulator on Hematopoietic Stem Cells in persistent Myelogenous Leukemia.- Suppressive impact of Interferon Alpha-2b on Hematopoietic Progenitor Cells in sufferers with persistent Myelogenous Leukemia.- scientific importance of Neutralizing Antibodies in sufferers with power Myelogenic Leukemia.- Cytostatic remedy of power Myelogenous Leukemia: assessment and Perspectives.- In Vivo results of Interferon-gamma in Chronic.- therapy of continual and Acute section persistent Myelogenous Leukemia with Interferon-Alpha-2b and Interferon- .- upkeep treatment of Busulfan-Induced persistent Granulocytic Leukemia Remissions with Interferon-Alpha-2b.- Allogeneic Bone Marrow Transplantation in persistent Myelogenous Leukemia.

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Extra resources for Chronic Myelocytic Leukemia and Interferon: Pathophysiological, Clinical and Therapeutical Aspects

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Nowell PC, Hungerford DA (1960) Aminute chromosome in human chronic granulocytic leukemia. Seience 132: 1497 37. Pugh WC, Pearson M, Vardiman JW, Row1ey JD (1985) Philadelphia chromosome-negative chronic myelogenous 1eukaemia: a morphological reassessment. Br J Haematol60: 457-467 38. Rodenhuis S, Smets RA, Slater RM, Behrendt H, Veerman AJP (1985) Distinguishing the Philadelphia chromosome of acute Iymphoblastic leukemia from its counterpart in chronic myelogenous leukemia. N Engl J Med 313: 51-52 39.

Circles, CFU-Meg; crosses, BFU-E; blacksquares, CFU-GM, day 12; whitesquares, CFU-TL colony type BFU-E CFU-E CFU-GM CFU-Meg Fig. 2. ICSO of rIFN-az for CFU-TL 200 400 1C50 600 600 U/ml various colony types in healthy donors (median values ± SD of five normal controls) Effect of Recombinant Interferon-Alpha-2 on the Growth 37 Effect 01 rIFN-02 on Colony Formation in PhI-positive CML Patients Microagar cultures were set up with bone marrow mononuclear cells of 13 Ph 1_ positive CML patients, two of whom had not been treated before the time of testing.

M. Price-Placzek for competent secretarial help during the preparation of this manuscript. Effect of Recombinant Interferon-Alpha-2 on the Growth 41 References 1. Bergsagel DE, Haas R, Messner HA (1986) Interferon alpha-2b in the treatment of chronie granulocytic leukemia. Semin Oncol3: 29-34 2. Gast! G, Aulitzky Q, Tilg H, Huber H, Hausmaninger H, Seewann HL, Prinoth P, Huber C (1987) Dose related effectiveness of alpha-interferon in chronic myelogenous 1eukemia. Blut 54: 1-2 3. Geissler D, Lu L, Bruno E, Yang HH, Broxmeyer HE, Hoffmann R (1986) The influence of T lymphocyte subsets and humoral factors on colony formation by human bone marrow and blood megakaryocyte progenitor cells in vitro.

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