By C. Fonatsch, G. Gradl (auth.), Prof. Dr. med. Dieter Huhn, Prof. Dr. med. Klaus Peter Hellriegel, Prof. Dr. med. Norbert Niederle (eds.)
Contents: Cytogenetic Findings in Myeloproliferative Disorders.- Molecular Analyses of persistent Myelocytic Leukemias.- Molecular organic research in persistent Myelogenous Leukemia sufferers present process Interferon Therapy.- impact of Recombinant Interferon-Alpha-2 at the progress of Hematopoietic Progenitor Cells in power Myelogenous Leukemia and Its courting to the medical Efficacy.- In Vitro results of Recombinant Human Tumor Necrosis Factor-Alpha and Interferon-Gamma on basic and Leukemic Myelopoiesis.- Demonstration of Interferon-Alpha Receptors in Cultured cellphone traces and in Myeloid Cells from sufferers with Acute or power Myeloid Leukemia.- Differential legislation of mobilephone Membrane Receptors for Interferon-Gamma and -Alpha on Peripheral Blood Cells of sufferers with persistent Myelogenous Leukemia in the course of Interferon-Gamma/-Alpha Therapy.- experiences of Interferon as a Regulator on Hematopoietic Stem Cells in persistent Myelogenous Leukemia.- Suppressive impact of Interferon Alpha-2b on Hematopoietic Progenitor Cells in sufferers with persistent Myelogenous Leukemia.- scientific importance of Neutralizing Antibodies in sufferers with power Myelogenic Leukemia.- Cytostatic remedy of power Myelogenous Leukemia: assessment and Perspectives.- In Vivo results of Interferon-gamma in Chronic.- therapy of continual and Acute section persistent Myelogenous Leukemia with Interferon-Alpha-2b and Interferon- .- upkeep treatment of Busulfan-Induced persistent Granulocytic Leukemia Remissions with Interferon-Alpha-2b.- Allogeneic Bone Marrow Transplantation in persistent Myelogenous Leukemia.
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Extra resources for Chronic Myelocytic Leukemia and Interferon: Pathophysiological, Clinical and Therapeutical Aspects
Nowell PC, Hungerford DA (1960) Aminute chromosome in human chronic granulocytic leukemia. Seience 132: 1497 37. Pugh WC, Pearson M, Vardiman JW, Row1ey JD (1985) Philadelphia chromosome-negative chronic myelogenous 1eukaemia: a morphological reassessment. Br J Haematol60: 457-467 38. Rodenhuis S, Smets RA, Slater RM, Behrendt H, Veerman AJP (1985) Distinguishing the Philadelphia chromosome of acute Iymphoblastic leukemia from its counterpart in chronic myelogenous leukemia. N Engl J Med 313: 51-52 39.
Circles, CFU-Meg; crosses, BFU-E; blacksquares, CFU-GM, day 12; whitesquares, CFU-TL colony type BFU-E CFU-E CFU-GM CFU-Meg Fig. 2. ICSO of rIFN-az for CFU-TL 200 400 1C50 600 600 U/ml various colony types in healthy donors (median values ± SD of five normal controls) Effect of Recombinant Interferon-Alpha-2 on the Growth 37 Effect 01 rIFN-02 on Colony Formation in PhI-positive CML Patients Microagar cultures were set up with bone marrow mononuclear cells of 13 Ph 1_ positive CML patients, two of whom had not been treated before the time of testing.
M. Price-Placzek for competent secretarial help during the preparation of this manuscript. Effect of Recombinant Interferon-Alpha-2 on the Growth 41 References 1. Bergsagel DE, Haas R, Messner HA (1986) Interferon alpha-2b in the treatment of chronie granulocytic leukemia. Semin Oncol3: 29-34 2. Gast! G, Aulitzky Q, Tilg H, Huber H, Hausmaninger H, Seewann HL, Prinoth P, Huber C (1987) Dose related effectiveness of alpha-interferon in chronic myelogenous 1eukemia. Blut 54: 1-2 3. Geissler D, Lu L, Bruno E, Yang HH, Broxmeyer HE, Hoffmann R (1986) The influence of T lymphocyte subsets and humoral factors on colony formation by human bone marrow and blood megakaryocyte progenitor cells in vitro.