By R. R. Love (auth.), Richard R. Love MD (eds.)
While our wisdom approximately melanoma is proliferating quickly, our rules of melanoma drugs for person sufferers and for populations are evolving basically progressively. Our primary figuring out of melanoma factors and deve lopment is incomplete, and our remedies are nonspecific and not more usually healing than we want. however, around the globe, our significant problem is still to use to our populations all that we all know approximately melanoma. to fulfill this problem, medical professionals in every single place desire a extensive view and lower than status of melanoma factors and regulate. This ebook is meant for doctors-in-training and medical clinical practi tioners; it presents ideas around the breadth of melanoma medication. The editors and authors think that it really is attainable to minimize the exposition of present wisdom to the compact forty chapters and six hundred pages awarded the following with out wasting the comprehensiveness, richness, and pragmatic element that medical professionals desire. This compilation presumes wisdom of the elemental sciences, really genetics, pathology, anatomy, and body structure. we've got attempted to stability clinical exposition with sensible fabric in preven tion, early detection, and palliative care, that are the key parts of pub lic wellbeing and fitness medication the place better awareness is required around the world. whereas this booklet relies, partly, on fabric ready for prior edi tions, each one bankruptcy has been newly written and edited by way of the authors and editorial employees for this edition.
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Journal of the National Cancer Institute 83:91-96 Pitot HC (1993) The molecular biology of carcinogenesis. Cancer 72:962-970 Tannock IF, Hill RP (eds) (1993) The basic science of oncology. Pergamon, New York Weinberg RA (1989) Oncogenes, anti-oncogenes and the molecular basis of multistep carcinogenesis. Cancer Research 49:3713-3721 17 2 Natural Histories of Cancers G. T. BRYAN Contents Cancers as Cellular Diseases Cancers as Temporal Diseases Cancers as Multietiologic Diseases Cancers as Multistage Diseases Initiation Growth Promotion Conversion Propagation Progression Cancers Invade and Metastasize Cancers Exhibit Uncontrolled and Irregular Growth Behavior Advanced Cancers Have Major Adverse Impacts on Patients Conclusions Evidence indicates that cancers are not new diseases, but have been present for millions of years.
Patterns are opposite for colon (Fig. 4b) and stomach (Fig. 4c) cancers. Colon cancer is predominant in the northern parts of Europe and the contrary is suggested for stomach cancer. The three cancer sites are related to dietary patterns. Pockets of low-risk areas for stomach cancer are observed in the southeast regions in France and low mortality from colon cancer tends to cluster in the more rural regions in Spain, Italy, and Greece, suggesting the protective effect of the diets in these areas.
The earliest drawings or writings from many ancient civilizations in all parts of the world have provided descriptions of cancers. Bone cancers and urinary bladder cancers have been diagnosed in Egyptian mummies. Writings of Hippocrates contained descriptions and recommended therapeutic procedures for cancers. It is clear from these writings that ancient physicians were aware that cancers exhibited spatial and temporal characteristics of progression and ultimately led to death. The natural histories of cancers describe and, where possible, explain the progressive steps and stages of cancer evolution in individuals and populations.